Naslov (srp)

Biomarkeri fibroza miokarda, nekroze miokarda, hemodinamskog stresa i inflamacije kod bolesnika koji se podvrgavaju hirurškoj revaskularizaciji miokarda

Autor

Mladenović, Nikola, 1989-

Doprinosi

Pavlović, Milan, 1956-
Velicki, Lazar, 1980-
Deljanin-Ilić, Marina, 1957-
Koraćević, Goran, 1961-
Veličković-Radovanović, Radmila, 1961-

Opis (srp)

Coronary heart disease is one of the most widespread diseases of the cardiovascularsystem. As a result, ischemic cardiomyopathy, myocardial infarction, myocardialfibrosis and valvular diseases develop. Treatment of coronary artery disease can beconservative and invasive. Invasive therapeutic approaches are percutaneouscoronary interventions and surgical revascularization of the myocardium, whichhave greatly contributed to prolonging life and improving the quality of life.Myocardial fibrosis is, among other things, a consequence of coronary disease,which is directly related to quality of life and survival. One of the newer biomarkersthat can be used to assess myocardial fibrosis is galectin-3, although it is not yet inroutine use. Myocardial fibrosis is also influenced by hemodynamic stress, whichcan be directly observed through the biomarker NT-proBNP, and markers ofinflammation and necrosis of the myocardium also have a significant impact. Inthis study, galectin-3 was investigated and compared with the values of NTproBNP,C-reactive protein (CRP) and creatine kinase MB (CK-MB) in coronarydisease treated by surgical myocardial revascularization. 110 patients participated,whose biomarker values were monitored preoperatively and on two occasionspostoperatively. The laboratory processing of the markers was carried out using theElisa method. The mutual relationship of the mentioned biomarkers was monitored,as well as the movement in relation to the complications recorded during thepostoperative period in terms of heart rhythm disorders, perioperative myocardialinfarction, central vascular ischemia, as well as the influence of spironolactone ontheir movement and overall connection. The results obtained are significant in thedirection of the level of galectin-3 as a marker whose early postoperative decreaseis associated with heart rhythm disturbances in the form of atrial fibrillation withabsolute ventricular response. It is also registered that patients who preoperativelyused spironolactone in their therapy had a statistically significantly lower incidenceof cardiac arrhythmia. No significant correlations were found between galectin-3levels and other biomarkers.

Opis (srp)

Biografija autora: list 113Bibliografija: list. 98-109 Datum odbrane: 18.7.2025. Internal medicine, cardiology

Jezik

srpski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 3.0 AT - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 3.0 Austria License.

http://creativecommons.org/licenses/by-nc-nd/3.0/at/legalcode