Naslov (srp)

Molekularni mehanizmi ishemijsko-reperfuzionog oštećenja tokom resekcije jetre

Autor

Gmijović, Marko, 1984-

Doprinosi

Stojanović, Miroslav, 1965-
Radojković, Milan, 1971-
Jevtović-Stoimenov, Tatjana, 1970-
Ignjatović, Nebojša, 1967-
Milić, Ljiljana, 1969-

Opis (srp)

Introduction: Bleeding during liver resection is a significant threat to the clinical outcome. The occlusion of the portal triad, inducing complete ischemia of the blood supply to the liver, is a well-documented, safe, and beneficial method for alleviating this problem. Although this technique is effective in limiting blood loss, there are still controversies regarding the potential drawbacks of ischemia and subsequent reperfusion injury to liver tissue. Material and Methods: The prospective study included 30 patients, average age of 62 years, who underwent liver resection surgery due to the neoplastic process or metastases of colorectal cancer. After obtaining informed consent, parameters were analyzed in three phases: preoperative, intraoperative, and postoperative. During the surgery (recommended by the surgeon/oncology board independent of our study), samples of "conditionally healthy liver tissue" (not affected by tumor processes) were taken. Following tissue homogenization, parameters responsible for the onset of liver tissue damage due to ischemia-reperfusion injury (IRI) were analyzed.Ethical standards: Based on the research findings, there were no direct influences noticed on the current clinical procedures, treatment processes, or the final treatment outcome among the patients involved in the study. Nevertheless, the insights obtained from this research may be beneficial for planning and conducting future liver resections in new patients. The analyses derived from this research could offer valuable guidelines for enhancing postoperative care and better understanding the factors impacting patient recovery after resection procedures.Conclusion: Using modern research methods, scientifically validated statistical data analysis, and appropriate literature, significant data about the nature or

Opis (srp)

Biografija autora: list 124Bibliografija: list. 115-122 Datum odbrane: 12.6.2024. Surgery, general surgery

Jezik

srpski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 3.0 AT - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 3.0 Austria License.

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