Naslov (srp)

Uticaj galektina-3 na remodelovanje miokarda i rani klinički ishod kod pacijenata sa akutnim infarktom miokarda

Autor

Andrejić, Olivera 1976-

Doprinosi

Pavlović, Milan 1956-
Tomašević, Miloje
Nikolić, Valentina

Opis (srp)

Biografija: list 106;Bibliografija: listovi 89-105. Datum odbrane: 06.02.2020. Cardiology

Opis (eng)

Our study investigated association between galectin-3 levels and adverse left ventricular remodelling at six months. Eighty-six patients following first AMI and stable angina (control group) were enrolled in this study and blood samples collected on day 1 from the femoral vein and artery, the right atrium near the coronary sinus and the aortic root; on day 5 from cubital vein and radial artery; on day 30 from the cubital vein. Patients with LVESV ≥ 20% at six months, were included in the LVR group. In patients with acute myocardial infarction, on day 1, Galectin-3 plasma levels in the femoral vein (10.34 ng/ml ± 3.81 vs 8.22 ng/ml ± 2.34, p=0.01), and coronary sinus (10.7 ng/ml ± 3.97 vs 8.41 ng/ml ± 2.56, p=0.007) were higher in the LVR group. Positive correlations between galectin-3 levels from aortic root and coronary sinus, aortic root and femoral vein, and coronary sinus and femoral vein were observed in both groups. On day 30, galectin-3 concentration in the cubital vein was an independent risk factor of LVR six months post-AMI, demonstrating 1.5-fold increased risk. Day-30 galectin-3 showed positive correlations with echocardiography parameters indicative of diastolic and systolic dysfunction. On day one galectin-3 levels in aortic root are significantly higher in patients with fatal outcome six months later. Determining galectin-3 plasma concentration on day 30 following AMI could have beneficial prognostic value in predicting LVR.

Jezik

srpski

Datum

2019

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 2.0 AT - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 2.0 Austria License.

http://creativecommons.org/licenses/by-nc-nd/2.0/at/legalcode