Stanje kapilarne mreže u makuli kod pacijenata sa dijabetesom bez klinički vidljive dijabetičke retinopatije u odnosu na zdravu populaciju
Introduction: Optical Coherence Tomography Angiography (OCT-A) was used toinvestigate the changes in retinal and choriocapillaris vessel density (VD) in patients affectedby type 2 diabetes mellitus (T2DM) with further investigation of alteration to theautoregulation of the capillary network in the macular zone occurs before the clinicalmanifestation of diabetic maculopathy or retinopathy. OCT-A biomarkers that indicate earlyvascular changes in the capillary bed were: central foveal thickness (CFT), the fovealavascular zone (FAZ), foveal density (FD), and vessel density (VD). The main aim was todetermine the state of the capillary network in the macula in patients with diabetes withoutclinically visible diabetic retinopathy in comparison to the healthy population.Method: A total of one hundred sixty-six eyes of 83 patients with T2DM and withoutdiabetic retinopathy, were recruited in this observational prospective study. The control groupconsisted of 66 eyes in 33 healthy subjects. Superficial capillary plexus (SCP), deep capillaryplexus (DCP), and choriocapillaris were regions where vessel density (VD) was measured.Results: There were significant differences in VD of the SCP and DCP among the controland study groups. The VD of the choriocapillaris revealed a statistically significant reductionin the study group in comparison to the control. The patients with T2DM showed asignificantly decreased VD concerning control in different macular regions. Thickness inseveral macular regions significantly decreased in the study group compared to the control.Useful information regarding the vascular changes in patients with T2DM were assessedthrough the quantitative analysis of retinal and choriocapillaris blood flow obtained withOCT-A. Diabetic subjects have a significantly higher mean value of CFT compared to themean value of the control group, followed by a significantly lower density of the capillarynetwork. In the case of the size of the FAZ, in diabetic patients, FAZ is enlarged but nostatistically significant difference was found.Conclusion: OCT-A parameters associated with retinal superficial and deep retinal vesseldensity have lower values detected in diabetic patients without DR in comparison to healthysubjects. Diabetes impacts the values of CFT and FD but does not impact the size of the FAZ.According to obtained results, OCT-A could be considered as a potential biomarker used forthe risk of developing DR in patients with diabetes without DR evaluation.
Beleška o autoru: list 112,Bibliografija: listovi 100-111. Datum odbrane: 06.07.2022. Ophthalmology
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