Naslov (srp)

Značaj optičke koherentne tomografije sa angiografijom u detekciji i analizi mikrovaskularnih promena optičkog diska i makule kod pacijenata sa miopijom

Autor

Veselinović, Марија Д., 1984-

Doprinosi

Trenkić, Marija, 1976-
Čanadanović, Vladimir, 1969-
Cekić, Sonja, 1973-

Opis (srp)

In recent decades, there has been a marked increase in the prevalence of myopia,which today represents one of the leading causes of visual impairment globally.High myopia carries a particular risk of developing irreversible pathologicalchanges affecting the retina and optic disc. The introduction of optical coherencetomography (OCT) and its angiographic variant (OCT-A) has enabled noninvasive,quantitative, and layer-specific analysis of microvascular and structural changesthat accompany the progression of myopia, which is of critical importance for theearly identification of high-risk patients. In this prospective observational study, atotal of 260 eyes from 130 participants were analyzed. Based on sphericalequivalent and axial length, subjects were classified into four diagnostic groups:emmetropia, low, moderate, and high myopia. Using OCT and OCT-A technology,multiple parameters were assessed, including axial length, central foveal thickness(CFD), retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), superficialand deep vascular densities (SVD, DVD), foveal avascular zone (FAZ) area,peripapillary vascular density (PVD), and the Flow Index (FI). The results showeda progressive increase in axial length and a simultaneous reduction in CFD, RNFL,and GCC in correlation with increasing refractive error. The most pronounceddifferences were observed in the superior and perifoveal regions. Vascular densitiesshowed a consistent decline across most sectors, with significant reductions in theperitemporal, perisuperior, and paranasal zones. The FAZ area increasedproportionally with the degree of myopia, while PVD and FI decreased markedly inhigh myopia patients. Correlation and regression analyses demonstrated strongassociations between vascular and structural parameters, especially in theparafoveal regions. Multivariate models confirmed the predictive value ofcombined SVD, DVD, and retinal layer measurements in estimating central fovealthickness, depending on the patient group. The findings indicate that microvascularalterations precede overt structural damage and may serve as early biomarkers ofmyopia progression. The integration of quantitative OCT and OCT-A parametersprovides a valuable tool for early detection of high-risk individuals and supportsindividualized monitoring strategies, ultimately contributing to the preservation ofvisual function.

Opis (srp)

Biografija autora: list 163Bibliografija: list. 142-158 Datum odbrane: 22.12.2025. Ophthalmology

Jezik

srpski

Datum

2025

Licenca

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