Naslov (srp)

Povezanost dermoskopskih karakteristika kutanih metastaza sa patohistološkim parametrima primarnog tumora i kliničkim karakteristikama pacijenata obolelih od melanoma

Autor

Popović, Danijela, 1971-

Doprinosi

Tiodorović-Živković, Danica, 1978-
Mijušković, Željko, 1969-
Kandolf Sekulović, Lidija, 1971-
Krstić, Miljan, 1973-
Petković, Ivan, 1976-

Opis (srp)

This scientific research aims to determine both clinical anddermoscopic characteristics of cutaneous metastases in patients withprimary cutaneous melanoma.Methodology: The dissertation examines the association ofdermoscopic characteristics of cutaneous metastases with thecharacteristics of primary melanoma, its histopathological features andlocalization, as well as the clinical characteristics of melanoma patientsmonitored after surgery at the Clinic for Dermatovenereology of theUniversity Clinical Center Niš, the Clinic for Oncology of theUniversity Clinical Center Niš, and the Clinic for Skin and VenerealDiseases of the Military Medical Academy in Belgrade, in the periodfrom 2020 to 2024. Dermoscopic patterns of cutaneous metastaseswere analyzed. Additionally, the types of structural patterns, additionaldermoscopic characteristics, and the dominant colour were determined.The relationships between the examined parameters were examinedusing statistical data processing.Significance of the research: The majority of cutaneous melanomametastases had a homogeneous pattern (43.8%), followed by a vascular(33.8%), saccular (12.5%), and polymorphic (10%) one. The frequencyof dermoscopic pattern types varied across different clinical types ofcutaneous melanoma metastases (flat and elevated) and betweenpigmented and non-pigmented lesions. Flat cutaneous metastases(macules) predominantly have a homogeneous pattern (72.7%), whileelevated cutaneous metastases (papules and nodules) most often havea vascular pattern (39.7%); the homogeneous pattern is dominant(65.3%) in pigmented cutaneous metastases, while the vascular patternprevails (87.5%) in non-pigmented ones. The type of dermoscopicpattern varies according to the type of primary cutaneous melanoma.In nodular melanoma, the prevailing patterns in its cutaneousmetastases are the homogeneous (46.3%) and vascular (36.6%) ones,while in acral lentiginous melanoma, the vascular pattern of cutaneousmetastases is the most frequent (50%). The presence of additionaldermoscopic characteristics is significantly more common in elevatedthan in flat cutaneous metastases. Non-pigmented cutaneousmetastases show a significantly higher frequency of blood vessels(96.8%) compared with the pigmented ones (32.7%). Mitoses weresignificantly more frequent in the histopathological findings of primarymelanoma in non-pigmented cutaneous metastases. In non-pigmentedmelanoma metastases, the predominant colour is red (77.4%), while inthe pigmented ones, it is blue (51%) and brown (34.7%).

Opis (srp)

Biografija kandidata: list 184Bibliografija: list. 155-183 Datum odbrane: 18.12.2025. Dermatovenerology, Pathology

Jezik

srpski

Datum

2025

Licenca

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