Naslov (srp)

Komparativna analiza odgovora tkiva na kolagenske biomaterijale primenjene na različite načine i u različitim animalnim modelima implantacije

Autor

Radenković Stošić, Milena B. 1990-

Doprinosi

Najman, Stevo, 1955-

Opis (srp)

Collagen-based biomaterials represents a popular choice for use intissue engineering, thanks to their biocompatibility, bioresorbabilityand the possibility of modification during the production process thatallows a control of stability and degradation time in the organism.Collagen used for the production of biomaterials can be obtained fromvarious sources, while taking into account the potential application ofcollagen-based biomaterial, which is conditioned by the method ofproduction and the source from which it was isolated. The aim of thisdoctoral dissertation was a comparative analysis of the tissue responseto collagen-based biomaterials of different species and tissue origin,different production method and structure, as well as with differentadditions of physiological factors such as blood and blood derivatives.The research was carried out on different experimental animalmodels, namely orthotopic ones, which involved the implantation ofdifferently prepared collagen-based biomaterials of different origininto the bone defects on rat calvaria and in the rabbit tibia models, aswell as the implantation of differently prepared collagen biomaterialsof different origin in the subcutaneous implantation models in miceand rats. The tissue response to the implanted collagen-basedbiomaterials was monitored and analyzed in several different timeperiods after implantation, and the explanted biomaterial sampleswith the surrounding tissue were analyzed using histological,immunohistochemical and histomorphometric methods as well asscanning electron microscopy.The results showed that collagen-based biomaterials originating fromnon-mammalian species, such as jellyfish, can be a suitablealternative source for collagen of mammalian origin in bone and softtissue regeneration. Collagens of different origins and productionmethods have different effects on bone tissue repair and causes adifferent response of subcutaneous and bone tissue, while the additionof blood and blood derivatives affects the resorption time of collagenbasedbiomaterials and tissue response. These findings emphasize theimportance of choosing the appropriate collagen-based biomaterial inaccordance with the conditions in which they are applied as well asapplied approaches in clinical application in order to achieve thedesired results in the field of regenerative medicine.

Opis (srp)

Biobibliografija autora: list. 189-193.Bibliografija: list. 161-181. Datum odbrane: 24.12.2024. Biomedicine

Jezik

srpski

Datum

2024

Licenca

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Creative Commons CC BY-NC-ND 3.0 AT - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 3.0 Austria License.

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