Komparativno ispitivanje lokalnog terapijskog dejstva probiotika, aktivnog kiseonika i klindamicin gela kod pacijenata sa hroničnom parodontopatijom
The aim of the study, which was conducted as a clinical prospectivestudy, was to determine the effectiveness of basic periodontal therapy,local application of probiotics, active oxygen and clindamycin gel afterbasic periodontal disease therapy in subjects with chronic periodontitis.Different approaches to the treatment of chronic periodontitis havebeen compared. In addition to basic (causal) therapy, which is the "goldstandard" in the treatment of chronic periodontitis, probiotic, activeoxygen and clindamycin gel therapy was used.All subjects underwent a detailed clinical examination and accurateanamnestic data were taken. The dental examination revealed a chronicform of periodontitis in all subjects, which was confirmed byradiological examination. Clinical parameters were determined beforetherapy, on the seventh day and 30 days after therapy. Subgingivalspecimens were collected before basic therapy and after 30 days toidentify the following bacterial species: Aggregatibacteractinomycetemcomitans, Porphyromonas gingivalis, Prevotellaintermedia, Tannerella forsythensis and Treponema denticola. Theresults were compared by clinical examination (oral hygiene indices,gingival and periodontal index) and polymerase chain reaction (PCR)by the method for testing periodontopathogenic bacteria.The study involved 160 respondents divided into 4 groups. The firstgroup consisted of 40 subjects with chronic periodontitis who receivedonly basic therapy (control group). The second group consisted of 40subjects with chronic periodontitis who were treated with probioticbacteria, Probiotic® (Ivančić and sons, Hemofarm Stada group, Vršac)in the periodontal pocket for 5 days.The third group consisted of 40 subjects with chronic periodontitiswho, after basic therapy, received active oxygen therapy in liquid form(Deverra, Farm DOO, Lebane) in the periodontal pocket for 5 days.The fourth group of subjects, a total of 40, with a chronic form ofperiodontitis, received basic periodontal therapy, after whichclindamycin gel (clindamycin hydrochloride gel 2%) was appliedtopically to the periodontal pocket, once.The clinical trial showed better results in groups II, III and IVcompared to the first control group of subjects in whom only basicperiodontal therapy was used. After therapy, a reduction in the presenceof the following bacterial species was found: Aggregatibacteractinomycetemcomitans, Porphyromonas gingivalis, Prevotellaintermedia, Tannerella forsythensis and Treponema denticola (p<0.001). Based on this clinical trial, it can be concluded that thecombined basic therapy and local application of probiotics and activeoxygen gave better results compared to the control group in which onlybasic therapy was used.
Beleška o autoru: list 133,Bibliografija: listovi 111-132. Datum odbrane: 07.11.2022. Parodontology
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